Can genetically engineered bacteria combat global obesity?

Obesity has become a world-wide epidemic that kills 2.8 million people every year. The number is rising day by day. This can also lead to certain complications like, nerve damage, renal failure, stroke, and the need for limb amputation. The main causes of obesity are: unhealthy diet, inactive lifestyle and perhaps some unlucky genes. In recent times, researchers have become more convinced that key players lie in human bowels: billions on billions of gut microbes. These vast and diverse assemblies of microbes work together, to help in regulation of metabolic, neurological, and immune systems. However, the harmony of this important microbial community is frequently threatened in people struggling with obesity, diabetes, or cardiovascular disease.

FDA has not approved too many medications so that obesity and related metabolic diseases can be effectively treated.

However, a group of researchers demonstrated that genetically altered gut bacteria, are the promising candidates to prevent weight gain. These genetically modified bacteria can colonize in the gut to prevent obesity and related disorders. They modified a probiotic strain of bacteria, Escherichia coli Nissle 1917 (EcN), to express high amounts of a hormone called N-acylphosphatidylethanolamine (NAPE). NAPE is naturally released by the small intestines when fat is being digested, and its active metabolites (N-acylethanolamides) send signals to the brain that suppress appetite. In fact obese people do not synthesize sufficient NAPE so they don’t have a feeling of satiation, so they eat more.

The team tested their NAPE-expressing bacteria by feeding high-fat diets to healthy mice while administering the bacteria in drinking water. After 8 weeks, the team noticed that mice treated with NAPE-expressing bacteria had only 50% of the body fat of mice receiving either control bacteria or standard drinking water. They also found a sustained reduction in food intake that lasted up to 6 weeks after treatment, resulting in lower body weights for at least 12 weeks after therapy.

One advantage of using laboratory-modified bacteria over the wild-type probiotics is that most beneficial bacteria don’t colonize the gut well. Using bacteria that are better-adapted to the gut means they’re more likely to take hold.

These modified bacteria are resistant to antibiotics, so that they can be easily grown in the lab for experiments. Though these bacteria haven’t shown any signs of being harmful, the researchers need to find an alternative before it can be used in humans. The alternative will also need to go rigorous testing to ensure that it does not pose any health risks.

The team now plans to optimize the bacteria for FDA approval and prepare for clinical trials in humans.

 

Reference

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. Chen Z, Guo L, Zhang Y, L Walzem R, Pendergast JS, Printz RL, Morris LC, Matafonova E, Stien X, Kang L, Coulon D, McGuinness OP, Niswender KD, Davies SS. J Clin Invest. 2014 Jun 24. pii: 72517.


The following two tabs change content below.
Arunima Maiti

Arunima Maiti

Biomedical scientist with special interest in reproductive biology.

You may also like...

92 Responses

  1. Avatar Catharine says:

    I do consider all of the concepts you’ve introduced for your post.
    They are very convincing and can certainly work. Still, the posts are
    too quick for starters. May you please extend them a bit from next
    time? Thanks for the post.

  2. I simply want to tell you that I’m all new to blogging and site-building and definitely loved this web-site. Very likely I’m planning to bookmark your site . You absolutely have superb stories. Thanks a bunch for revealing your blog.

  3. Arunima Maiti Arunima Maiti says:

    Thanks a lot for your for your appreciation and your friendly advice.

  4. Avatar page says:

    I simply want to say I am very new to blogs and certainly savored your blog site. Almost certainly I’m want to bookmark your site . You absolutely have awesome writings. Thanks a bunch for revealing your web-site.

  5. I am not sure where you’re getting your info, but great topic. I needs to spend some time learning more or understanding more. Thanks for fantastic info I was looking for this info for my mission.

  6. Its like you read my mind! You seem to know so much about this, like you wrote the book in it or something. I think that you can do with some pics to drive the message home a bit, but other than that, this is magnificent blog. A fantastic read. I will definitely be back.

  7. Avatar Serina Valla says:

    Fantastic beat ! I wish to apprentice while you amend your website, how could i subscribe for a blog web site? The account aided me a acceptable deal. I had been a little bit acquainted of this your broadcast provided bright clear concept

  8. I don’t even know how I ended up here, but I thought this post was good. I don’t know who you are but definitely you are going to a famous blogger if you aren’t already 😉 Cheers!

  9. Avatar good link says:

    Aw, this was a really good post. Spending some time and actual effort to produce a superb article… but what can I say… I hesitate a whole lot and don’t seem to get nearly anything done.

  10. Avatar Nikki Goldie says:

    Its like you read my mind! You seem to know so much about this, like you wrote the book in it or something. I think that you can do with a few pics to drive the message home a bit, but instead of that, this is excellent blog. A fantastic read. I’ll certainly be back.

  11. This is really interesting, You are a very skilled blogger. I have joined your feed and look forward to seeking more of your wonderful post. Also, I have shared your web site in my social networks!

  12. My brother suggested I might like this web site. He was entirely right. This post actually made my day. You cann’t imagine just how much time I had spent for this info! Thanks!

  13. I think this is one of the most important information for me. And i’m glad reading your article. But wanna remark on some general things, The web site style is great, the articles is really great : D. Good job, cheers

  14. Avatar go here says:

    You are so cool! I don’t suppose I have read through something like that before. So nice to find another person with some genuine thoughts on this subject. Really.. thanks for starting this up. This site is something that is required on the internet, someone with a bit of originality!

  15. A powerful share, I just given this onto a colleague who was doing slightly analysis on this. And he in fact bought me breakfast as a result of I discovered it for him.. smile. So let me reword that: Thnx for the deal with! However yeah Thnkx for spending the time to discuss this, I really feel strongly about it and love reading extra on this topic. If doable, as you become experience, would you mind updating your weblog with extra details? It is highly useful for me. Massive thumb up for this weblog post!

  16. Its like you read my mind! You seem to know a lot about this, like you wrote the book in it or something. I think that you could do with a few pics to drive the message home a little bit, but other than that, this is magnificent blog. A fantastic read. I’ll certainly be back.

  17. Magnificent beat ! I would like to apprentice while you amend your web site, how can i subscribe for a blog site? The account aided me a acceptable deal. I had been tiny bit acquainted of this your broadcast offered bright clear concept

  18. I loved as much as you’ll receive carried out right here. The sketch is tasteful, your authored material stylish. nonetheless, you command get bought an shakiness over that you wish be delivering the following. unwell unquestionably come more formerly again since exactly the same nearly a lot often inside case you shield this hike.

  19. I love what you guys tend to be up too. This kind of clever work and coverage! Keep up the awesome works guys I’ve added you guys to blogroll.

  20. Avatar Jay Dueitt says:

    I do not even know how I ended up here, but I thought this post was good. I don’t know who you are but certainly you’re going to a famous blogger if you are not already 😉 Cheers!

  21. hey there and thank you for your information – I have certainly picked up something new from right here. I did however expertise several technical points using this web site, since I experienced to reload the website lots of times previous to I could get it to load properly. I had been wondering if your web host is OK? Not that I’m complaining, but sluggish loading instances times will very frequently affect your placement in google and could damage your quality score if advertising and marketing with Adwords. Anyway I am adding this RSS to my email and could look out for a lot more of your respective interesting content. Make sure you update this again very soon..

  22. Oh my goodness! Amazing article dude!

  23. Avatar Tawna Franz says:

    I like the valuable information you provide in your articles. I will bookmark your weblog and check again here frequently. I’m quite certain I will learn plenty of new stuff right here! Best of luck for the next!

  24. Aw, this was an incredibly good post. Spending some time and actual effort to create a superb article… but what can I say… I procrastinate a lot and don’t manage to get anything done.

  25. Avatar good link says:

    A motivating discussion is worth comment. I do think that you ought to write more on this subject matter, it may not be a taboo subject but generally people do not speak about these topics. To the next! Many thanks!!

  26. I intended to send you the tiny observation to thank you once again for those extraordinary concepts you’ve provided in this article. It was so surprisingly generous with people like you giving easily all a number of us would’ve sold as an electronic book to generate some cash for themselves, most notably since you could have done it in case you considered necessary. Those principles as well served like the good way to comprehend other individuals have a similar dreams like my very own to understand a whole lot more with regard to this matter. I’m sure there are numerous more pleasurable times ahead for individuals that read carefully your site.

  27. Great blog here! Also your site loads up very fast! What web host are you using? Can I get your affiliate link to your host? I wish my website loaded up as fast as yours lol

  28. Unquestionably believe that which you stated. Your favorite justification appeared to be on the net the simplest thing to be aware of. I say to you, I certainly get annoyed while people think about worries that they just don’t know about. You managed to hit the nail upon the top and defined out the whole thing without having side effect , people could take a signal. Will probably be back to get more. Thanks

  29. A motivating discussion is worth comment. I think that you ought to write more on this subject, it might not be a taboo subject but typically people do not talk about these issues. To the next! Best wishes!!

  30. My brother suggested I might like this website. He was totally right. This post actually made my day. You can not imagine just how much time I had spent for this information! Thanks!

  31. I think this is among the most significant information for me. And i am glad reading your article. But want to remark on some general things, The website style is ideal, the articles is really excellent : D. Good job, cheers

  32. I was suggested this blog by my cousin. I’m not sure whether this post is written by him as nobody else know such detailed about my problem. You are amazing! Thanks!

  33. Avatar good link says:

    I was more than happy to uncover this website. I want to to thank you for ones time for this wonderful read!! I definitely liked every little bit of it and I have you book-marked to look at new things in your site.

  34. Avatar Kerry Sprigg says:

    Hey There. I found your blog using msn. This is a really well written article. I will make sure to bookmark it and come back to read more of your useful info. Thanks for the post. I will certainly return.

  35. I’ve been surfing online more than three hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. In my opinion, if all website owners and bloggers made good content as you did, the net will be a lot more useful than ever before.

  36. Hello there, You have done an incredible job. I will definitely digg it and personally recommend to my friends. I’m sure they’ll be benefited from this site.

  37. This web site is really a walk-through for all of the info you wanted about this and didn’t know who to ask. Glimpse here, and you’ll definitely discover it.

  38. Hello there, just became aware of your blog through Google, and found that it is truly informative. I’m gonna watch out for brussels. I’ll be grateful if you continue this in future. Many people will be benefited from your writing. Cheers!

  39. Avatar Helen Laredo says:

    Pretty section of content. I just stumbled upon your blog and in accession capital to assert that I get in fact enjoyed account your blog posts. Any way I will be subscribing to your feeds and even I achievement you access consistently quickly.

  40. Avatar Inez Xang says:

    Thank you for the auspicious writeup. It in fact was a amusement account it. Look advanced to more added agreeable from you! By the way, how can we communicate?

  41. This is really interesting, You’re a very skilled blogger. I’ve joined your feed and look forward to seeking more of your magnificent post. Also, I’ve shared your site in my social networks!

  42. Unquestionably believe that which you stated. Your favorite justification appeared to be on the net the easiest thing to be aware of. I say to you, I certainly get irked while people consider worries that they just don’t know about. You managed to hit the nail upon the top and defined out the whole thing without having side effect , people can take a signal. Will likely be back to get more. Thanks

  43. Avatar Damien Abegg says:

    Excellent blog here! Also your site loads up very fast! What host are you using? Can I get your affiliate link to your host? I wish my website loaded up as fast as yours lol

  44. very nice post, i certainly love this website, keep on it

  45. hello there and thank you for your info – I’ve certainly picked up something new from right here. I did however expertise some technical points using this site, since I experienced to reload the web site lots of times previous to I could get it to load properly. I had been wondering if your hosting is OK? Not that I’m complaining, but slow loading instances times will sometimes affect your placement in google and can damage your quality score if ads and marketing with Adwords. Anyway I’m adding this RSS to my email and can look out for much more of your respective interesting content. Make sure you update this again soon..

  46. Very nice post. I just stumbled upon your weblog and wished to say that I have truly enjoyed surfing around your blog posts. In any case I will be subscribing to your feed and I hope you write again very soon!

  47. Hi, i think that i saw you visited my website thus i came to “return the favor”.I’m attempting to find things to enhance my website!I suppose its ok to use some of your ideas!!

  48. I think this is one of the most important information for me. And i’m glad reading your article. But want to remark on few general things, The web site style is perfect, the articles is really great : D. Good job, cheers

  49. This design is wicked! You most certainly know how to keep a reader amused. Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Wonderful job. I really loved what you had to say, and more than that, how you presented it. Too cool!

  50. Avatar Willie Cinco says:

    I think this is one of the most important information for me. And i’m glad reading your article. But should remark on few general things, The web site style is wonderful, the articles is really excellent : D. Good job, cheers

  51. Avatar Click here says:

    Sorry for the huge review, but I’m really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it’s the right choice for you.

  52. I have been surfing online more than 3 hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. In my view, if all web owners and bloggers made good content as you did, the internet will be a lot more useful than ever before.

  53. I don’t even know how I ended up here, but I thought this post was good. I don’t know who you are but certainly you are going to a famous blogger if you are not already 😉 Cheers!

  54. hello there and thank you in your info – I’ve definitely picked up something new from right here. I did alternatively expertise a few technical issues the usage of this site, since I experienced to reload the website lots of instances previous to I may get it to load correctly. I had been pondering if your hosting is OK? Not that I am complaining, however sluggish loading cases times will very frequently affect your placement in google and could injury your quality rating if advertising and ***********|advertising|advertising|advertising and *********** with Adwords. Well I’m including this RSS to my email and can look out for a lot extra of your respective exciting content. Ensure that you replace this once more soon..

  55. I have been browsing online more than 3 hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. In my view, if all site owners and bloggers made good content as you did, the net will be a lot more useful than ever before.

  56. I have been exploring for a little for any high quality articles or weblog posts on this kind of area . Exploring in Yahoo I at last stumbled upon this website. Reading this information So i’m glad to exhibit that I have a very excellent uncanny feeling I found out just what I needed. I such a lot undoubtedly will make certain to do not forget this web site and provides it a look regularly.

  57. Simply wish to say your article is as amazing. The clearness in your post is just nice and i can assume you’re an expert on this subject. Well with your permission allow me to grab your RSS feed to keep updated with forthcoming post. Thanks a million and please carry on the gratifying work.

  58. Avatar Lukas says:

    I am sure this piece of writing has touched all thee internet
    viewers, its really really nice paragraph on building up new website.

  59. Avatar blog says:

    I am extremely inspired along with your writing talents and also with the structure in your blog. Is that this a paid subject matter or did you modify it yourself? Either way stay up the excellent high quality writing, it is rare to look a nice weblog like this one nowadays..

  60. Avatar Clay Gilford says:

    Hey There. I found your blog using msn. This is an extremely well written article. I’ll make sure to bookmark it and return to read more of your useful information. Thanks for the post. I’ll definitely comeback.

  61. Avatar Gail Torello says:

    Oh my goodness! Awesome article dude! Thanks, However I am going through issues with your RSS. I don’t know the reason why I can’t join it. Is there anybody else having similar RSS issues? Anyone who knows the answer can you kindly respond? Thanx!!

  62. Avatar Kris Evensen says:

    I together with my guys ended up studying the nice guidelines found on the website then all of the sudden came up with a horrible suspicion I never expressed respect to the web blog owner for those secrets. All the women happened to be as a consequence passionate to read all of them and have in fact been tapping into them. Thank you for actually being quite considerate as well as for figuring out this form of tremendous resources millions of individuals are really needing to discover. Our honest apologies for not saying thanks to earlier.

  63. It is the best time to make some plans for the future and it’s time to be happy. I have read this post and if I could I want to suggest you some interesting things or tips. Perhaps you can write next articles referring to this article. I wish to read even more things about it!

  64. Hello! I could have sworn I’ve been to this blog before but after looking at some of the articles I realized it’s new to me. Regardless, I’m definitely delighted I found it and I’ll be bookmarking it and checking back regularly!

  65. Does your blog have a contact page? I’m having trouble locating it but, I’d like to send you an email. I’ve got some creative ideas for your blog you might be interested in hearing. Either way, great blog and I look forward to seeing it expand over time.

  66. Spot on with this write-up, I truly feel this web site needs far more attention. I’ll probably be returning to see more, thanks for the info!

  67. Avatar Naida Pasey says:

    Pretty nice post. I just stumbled upon your weblog and wished to say that I’ve really enjoyed browsing your blog posts. In any case I’ll be subscribing to your rss feed and I hope you write again soon!

  68. Avatar Darrell says:

    I seriously love your site.. Very nice colors & theme.
    Did you create this web site yourself? Please reply back as I’m trying to create my own blog and want to find out where
    you got this from or exactly what the theme is called.
    Many thanks!

  69. I do agree with all of the ideas you’ve offered on your post. They are very convincing and can definitely work. Nonetheless, the posts are very quick for starters. Could you please prolong them a bit from subsequent time? Thank you for the post.

  70. Avatar Cyril says:

    I like the helpful info you supply in your articles.
    I will bookmark your blog and check once more right
    here regularly. I’m fairly certain I will be told
    lots of new stuff right right here! Good luck for the following!

  71. Avatar Noreen says:

    Hi there, after reading this awesome piece of writing i am too delighted to share my familiarity here with colleagues.

  72. Avatar pippepay.com says:

    Excellent blog here! Also your web site loads up fast!

    What web host are you using? Can I get your affiliate link to your host?
    I wish my website loaded up as fast as yours lol

  73. Avatar Google says:

    Usually posts some incredibly interesting stuff like this. If you

  74. Avatar cialis says:

    I happen to be writing to make you understand of the wonderful experience my cousin’s daughter obtained visiting the blog. She even learned so many details, which included what it is like to have a very effective giving character to let other people just gain knowledge of selected complex subject areas. You really surpassed our expected results. Thank you for imparting these invaluable, dependable, edifying not to mention unique guidance on your topic to Jane.

  75. Avatar Jayson says:

    Hi to every body, it’s my first go to see of this blog;
    this web site includes awesome and actually fine
    stuff designed for readers.

  76. This site certainly has all the info I wanted about this subject and didn’t know who to ask.

  77. Avatar Dessie says:

    Hello there, just became aware of your blog through Google,
    and found that it’s really informative. I’m gonna watch out for
    brussels. I will be grateful if you continue this in future.
    Numerous people will be benefited from your writing.
    Cheers!

  78. Avatar Priscilla says:

    Hey! This post could not be written any better!
    Reading this post reminds me of my old room mate! He always kept chatting
    about this. I will forward this page to him.
    Fairly certain he will have a good read. Thank you for sharing!

  79. Avatar Elizabet says:

    Everything is very open with a very clear explanation of the challenges.
    It was really informative. Your site is very useful. Many thanks
    for sharing!

  80. Avatar Inez says:

    What’s up everybody, here every person is sharing these kinds of experience, therefore it’s good to read this blog,
    and I used to go to see this blog daily.

  81. Avatar Kira says:

    Hello all, here every person is sharing these familiarity, therefore it’s fastidious to read this
    webpage, and I used to visit this web site all the time.

  82. Avatar Aiden says:

    I was able to find good advice from your blog articles.

  83. Avatar Chung Cashon says:

    Truly insightful bless you, I am sure your current visitors could quite possibly want even more posts of the nature maintain the excellent get the job done.

  84. Avatar RN says:

    The details talked about within the post are several of the best offered

  85. Avatar Jack Chaobal says:

    Omg, like!!! The interaction amongst the 2 is remarkable. So are your pictures

  86. Avatar Caridad says:

    It’s wonderful that you are getting ideas from this article as
    well as from our argument made here.

  87. Avatar Twila says:

    hello!,I love your writing so so much! percentage we communicate extra about your post on AOL?
    I require a specialist in this area to unravel my problem.
    May be that’s you! Looking forward to peer you.

  88. Avatar Juliet says:

    Your means of describing the whole thing in this
    article is really fastidious, all be able to easily understand it, Thanks a
    lot.

  89. Avatar Russel says:

    I am sure this paragraph has touched all the internet visitors, its really really pleasant piece of writing on building up new webpage.

  90. Avatar Valentina says:

    I would like to thank you for the efforts you’ve put in writing this website.
    I really hope to view the same high-grade blog posts from you later on as well.
    In truth, your creative writing abilities has
    inspired me to get my own, personal website now 😉

Leave a Reply

Your email address will not be published. Required fields are marked *

Blue Captcha Image
Refresh

*